The Xhemalce lab aims to decipher how epigenetic modifications modulate the molecules that mediate the expression of genetic information from DNA to RNA to proteins, with a particular focus on the microRNA pathway. Our ultimate goal is to identify enzymes "writers" or "erasers" of epigenetic modifications that are potential targets for therapeutic drugs for the treatment of human diseases such as cancer. One such enzyme is BCDlN3D, which Dr. Blerta Xhemalce recently showed to be a methyltransferase that regulates processing of microRNAs by Dicer through direct methylation of their RNA precursors.
Blerta Xhemalce, PhD
Department of Molecular Biosciences &
Institute for Cellular and Molecular Biology
University of Texas at Austin