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The Xhemalçe lab aims to decipher how epigenetic modifications regulate the expression of genetic information from DNA to RNA to proteins, with a particular focus on RNA modification pathways. We use a combination of cellular and molecular biology, RNA biochemistry, next generation sequencing and quantitative mass spectrometry to identify and characterise novel "writers", "erasers" and "readers" of RNA modifications. The objective is to identify fundamental biological mechanisms of gene regulation, as well as potential therapeutic targets for cancer and metabolic diseases.
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